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KMID : 0363219920300030334
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Korean Journal of Dermatology
1992 Volume.30 No. 3 p.334 ~ p.339
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Effect of Dietary Zinc Deficiency on the Enzymatic Components of Free Radical Defense System in the Skin of Rats
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Abstract
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The effect of dietary zinc deficiency on the enzymatic components of free radical defense system was observed in the skin of rats. We masured the concentration of serum zinc and the enzymatic activities of CuZn superoxide dismutase (CkuZn SOD),
glucose-6-phosphate de hydrogenase (G6PDH) and glutathione reductase (GSH-RD). The serum zine level was significantly lower in the zinc-deficient group compared to the zinc-supplemented group after 8 weeks of consuming the diet (P<0.01). cuZn SOD
activity was not different between the two groups after 4 weeks. The Zn deficient groups showed the significantly decreased activity of G6PDH after 4 and 8 weeks of consuming the diet (P<0.01). The activity of GSH-RD was increased in the
zine-deficient
group compared to the supplemented group after 4 weeks of consuming the diet (P<0.01), but after 8 weeks the activity was not different between the two groups. From the results obtained, it could be concluded that GSH-RD may contribute to the
oxygen
free radical defense system in zinc deficiency in the earlier weeks of consum ing the zinc-deficient diet. (Kor J Dermatol 1992 : 30(3) : 334-339)
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